Article
The interleukin-8-251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pylori-infected Koreans.
Journal of clinical gastroenterology - 1 Mar 2009
Ye Byong Duk, Kim Sang Gyun, Park Ji Hyun, Kim Joo Sung, Jung Hyun Chae, Song In Sung
Abstract excerpt
BACKGROUND AND GOALS: Chronic inflammation associated with Helicobacter pylori infection is a risk factor of gastric adenocarcinoma. Interleukin-8 (IL-8) plays an important role in gastric mucosal inflammation induced by H. pylori infection. Recently, studies on the association of genetic polymorphisms of various proinflammatory cytokines with gastric carcinogenesis showed varying results on the basis of the...
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