Article
An interleukin-1beta (IL-1beta) single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of IL-1beta in diseased periodontal tissues.
Infection and immunity - 1 Aug 2008
Ferreira Samuel B, Trombone Ana Paula F, Repeke Carlos E, Cardoso Cristina R, Martins Walter, Santos Carlos F, Trevilatto Paula Cristina, Avila-Campos Mario J, Campanelli Ana Paula, Silva João S, Garlet Gustavo P
Abstract excerpt
Inflammatory cytokines such as interleukin-1beta (IL-1beta) are involved in the pathogenesis of periodontal diseases. A high individual variation in the levels of IL-1beta mRNA has been verified, which is possibly determined by genetic polymorphisms and/or by the presence of periodontopathogens such as Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Aggregatibacter actinomycetemcomitans....
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