Article
Tumor necrosis factor-alpha -308G/A single nucleotide polymorphism and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-alpha in diseased periodontal tissues.
Journal of periodontal research - 1 Oct 2009
Trombone A P F, Cardoso C R, Repeke C E, Ferreira S B, Martins W, Campanelli A P, Avila-Campos M J, Trevilatto P C, Silva J S, Garlet G P
Abstract excerpt
BACKGROUND AND OBJECTIVE: Inflammatory cytokines such as tumor necrosis factor-alpha are involved in the pathogenesis of periodontal diseases. A high between-subject variation in the level of tumor necrosis factor-alpha mRNA has been verified, which may be a result of genetic polymorphisms and/or the presence of periodontopathogens such as Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola...
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