Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent.

doi:10.1371/journal.pone.0186366

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Article

Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent.

PloS one - 1 Jan 2017

Mesa Francisco, Lanza Esperanza, García Llenalia, Marfil-Alvarez Rafael, Magan-Fernandez Antonio

Abstract excerpt

Interleukin (IL) 1-ra is a potent endogenous competitive inhibitor of IL-α and β and has an anti-inflammatory role. Study objectives were: 1) to assess the associations of IL-1RN genetic single nucleotide polymorphism (SNP) (rs419598) with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and absence of periodontitis and 2) to assess its association with the load of five...

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PMID: 29023524
DOI: 10.1371/journal.pone.0186366
PMCID: PMC5638498

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