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Article

Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII.

The Journal of biological chemistry - 22 Aug 2008

Jiang Lily I, Collins Julie, Davis Richard, Fraser Iain D, Sternweis Paul C

Abstract excerpt

Regulation of intracellular cAMP by multiple pathways enables differential function of this ubiquitous second messenger in a context-dependent manner. Modulation of G(s)-stimulated intracellular cAMP has long been known to be modulated by the G(i) and G(q)/Ca(2+) pathways. Recently, the G(13) pathway was also shown to facilitate cAMP responses in murine macrophage cells. We report here that this synergistic...

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Share to Adenylyl Cyclases
Share to Cell Membrane
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to GTP-Binding Protein alpha Subunits, G12-G13

Share to Macrophages

Share to Models, Biological

Share to RNA Interference

Source

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Identifiers

PMID: 18541530
DOI: 10.1074/jbc.M803281200
PMCID: PMC2516994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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