Article
Genetic variant in glutathione peroxidase 1 gene is associated with an increased risk of coronary artery disease in a Chinese population.
Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2008
Tang Na-Ping, Wang Lian-Sheng, Yang Li, Gu Hai-Juan, Sun Qing-Min, Cong Ri-Hong, Zhou Bo, Zhu Huai-Jun, Wang Bin
Abstract excerpt
BACKGROUND: Glutathione peroxidase 1 (GPX1), the key antioxidant enzyme in vascular endothelial cells, has been shown to exert a protective effect against the presence of coronary artery disease (CAD). The 198Pro/leu variant, located at codon 198 of GPX1 gene, has recently been linked to cardiovascular disease, but data were inconsistent. We investigated the association between the occurrence of CAD and the...
Topics
- Aged
- Alleles
- Asian People
- Case-Control Studies
- China
- Coronary Artery Disease
- Data Interpretation, Statistical
- Female
- Genetic Variation
- Genotype
- Glutathione Peroxidase
- Humans
- Male