Article
Changes in retinoic acid signaling alter otic patterning.
Development (Cambridge, England) - 1 Jul 2007
Hans Stefan, Westerfield Monte
Abstract excerpt
Retinoic acid (RA) has pleiotropic functions during embryogenesis. In zebrafish, increasing or blocking RA signaling results in enlarged or reduced otic vesicles, respectively. Here we elucidate the mechanisms that underlie these changes and show that they have origins in different tissues. Exces...
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