Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline.

doi:10.1016/j.neurobiolaging.2008.04.014

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Article

Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline.

Neurobiology of aging - 1 Feb 2010

Payton Antony, Miyajima Fabio, Ollier William, Rabbitt Patrick, Pickles Andrew, Weiss Volkmar, Pendleton Neil, Horan Michael

Abstract excerpt

NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines. We have investigated a functional non-synonymous exon 3 single nucleotide polymorphism...

Topics

Cognition Disorders
Cohort Studies
Female
Humans
Male
Mental Recall
Middle Aged
Mutation, Missense
NAD(P)H Dehydrogenase (Quinone)
Neuropsychological Tests
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Time Factors

Source

Open in PubMed

Identifiers

PMID: 18538895
DOI: 10.1016/j.neurobiolaging.2008.04.014

Genes

NQO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-18538895-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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