Article
Expression patterns and polymorphisms of PTCH in Chinese hepatocellular carcinoma patients.
Experimental and molecular pathology - 1 Jun 2008
Fu Xinhui, Wang Qian, Chen Xilin, Huang Xiaohui, Cao Liangqi, Tan Haoxiang, Li Wen, Zhang Longjuan, Bi Jiong, Su Qiao, Chen Lianzhou
Abstract excerpt
Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors. PTCH (PTCH1), the receptor of Hedgehog pathway, is reported to function as a gatekeeper in tumor formation. Here we report, by semi-quantitative RT-PCR, PTCH expression was found in 38 hepatocellular carcinoma (HCC) patients (66%). Evidences from real time quantitative RT-PCR further indicate that...
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