Article
Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.
Psychiatry research - 30 Oct 2011
Houston John P, Kohler Jared, Ostbye Katherine M, Heinloth Alexandra, Perlis Roy H
Abstract excerpt
Single-nucleotide and diplotype associations with 17-item Hamilton Depression Rating Scale (HAMD(17)) total score changes were examined, based on catechol-O-methyltransferase (COMT) rs165599 status in duloxetine-treated, self-identified white patients with major depressive disorder. COMT rs165737 and a diplotype containing COMT rs165599 and COMT rs165737 were associated with HAMD(17) total score changes.
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