Article
Mutations of the ING1 tumor suppressor gene detected in human melanoma abrogate nucleotide excision repair.
International journal of oncology - 1 Jul 2004
Campos Eric I, Martinka Magdalena, Mitchell David L, Dai Derek L, Li Gang
Abstract excerpt
Epidemiological evidence indicates that ultraviolet radiation (UVR) is the primary environmental cause of the rapid increase in the incidence of human cutaneous melanoma observed in the past decades. However, the genetic changes caused by UVR that lead to melanoma formation remain unclear. The ING1 (inhibitor of growth 1) tumor suppressor plays an important role in cellular stress response to UVR. To further...
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