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Alcohol-induced epigenetic changes prevent fibrosis resolution after alcohol cessation in miceresolution

9 Nov 2023

Abstract excerpt

BACKGROUND AND AIMS: Alcohol-associated liver disease is a major cause of alcohol-associated mortality. Recently, we identified hepatic demethylases lysine demethylase (KDM)5B and KDM5C as important epigenetic regulators of alcohol response in the liver. In this study, we aimed to investigate the role of KDM5 demethylases in alcohol-associated liver disease resolution. APPROACH AND RESULTS: We showed that...

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PMID: 37943941
DOI: 10.1097/hep.0000000000000675

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