Article
Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner.
Neuron - 18 Jul 2002
Pennetta Giuseppa, Hiesinger Peter Robin, Fabian-Fine Ruth, Meinertzhagen Ian A, Bellen Hugo J
Abstract excerpt
Aplysia VAP-33 (VAMP-associated protein) has been previously proposed to be involved in the control of neurotransmitter release. Here, we show that a Drosophila homolog of VAP-33, DVAP-33A, is localized to neuromuscular junctions. Loss of DVAP-33A causes a severe decrease in the number of boutons and a corresponding increase in bouton size. Conversely, presynaptic overexpression of DVAP-33A induces an increase in...
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