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Article

A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2008

Wang Meilin, Zhang Zhizhong, Zhu Haixia, Fu Guangbo, Wang Shouyu, Wu Dongmei, Zhou Jianwei, Wei Qingyi, Zhang Zhengdong

Abstract excerpt

PURPOSE: MDM2 is believed to regulate the p53 level in modulating DNA repair, cell cycle control, cell growth, and apoptosis. We hypothesize that genetic variants in the MDM2 gene are associated with risk of bladder cancer. EXPERIMENTAL DESIGN: We first conducted a case-control study of 234 bladder cancer cases and 253 cancer-free controls, using the haplotype-based tagging single nucleotide polymorphism (SNP)...

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Source

Identifiers

PMID: 18519798
DOI: 10.1158/1078-0432.CCR-07-5155

Genes

MDM2
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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