Article
Genetic variants of the copy number polymorphic beta-defensin locus are associated with sporadic prostate cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2008
Huse Klaus, Taudien Stefan, Groth Marco, Rosenstiel Philip, Szafranski Karol, Hiller Michael, Hampe Jochen, Junker Kerstin, Schubert Jorg, Schreiber Stefan, Birkenmeier Gerd, Krawczak Michael, Platzer Matthias
Abstract excerpt
BACKGROUND/AIMS: Prostate cancer represents the cancer with the highest worldwide prevalence in men. Chromosome 8p23 has shown suggestive genetic linkage to early-onset familial prostate cancer and is frequently deleted in cancer cells of the urogenital tract. Within this locus some beta-defensin genes (among them DEFB4, DEFB103, DEFB104) are localized, which are arranged in a gene cluster shown to exhibit an...
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