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Article

The canine model with chronic, complete atrio-ventricular block.

Pharmacology & therapeutics - 1 Aug 2008

Oros Avram, Beekman Jet D M, Vos Marc A

Abstract excerpt

Proarrhythmic susceptibility to drug-induced Torsades de Pointes is restricted to individuals with a predisposed phenotype characterized by a reduced repolarization reserve. Additional factors are often involved in a further impairment of repolarization, possibly culminating with dangerous ventricular polymorphic tachyarrhythmias. Drugs that block repolarizing currents represent such an additional hit. The dog...

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Identifiers

PMID: 18514320
DOI: 10.1016/j.pharmthera.2008.03.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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