Article
The Candida albicans Ddr48 protein is essential for filamentation, stress response, and confers partial antifungal drug resistance.
Medical science monitor : international medical journal of experimental and clinical research - 1 Jun 2008
Dib Leila, Hayek Peter, Sadek Helen, Beyrouthy Berna, Khalaf Roy A
Abstract excerpt
BACKGROUND: Candida albicans is a dimorphic pathogenic fungus that causes mucosal and systemic infections. C. albicans pathogenicity is attributed to its ability to exist in different morphologic states and to respond to stress by up regulating several key genes. DDR48 is a stress-associated gene involved in DNA repair and in response to antifungal drug exposure. MATERIAL/METHODS: One allele of DDR48 was knocked...
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