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JCPyV-Induced MAPK Signaling Activates Transcription Factors during Infection

26 Sept 2019

Abstract excerpt

JC polyomavirus (JCPyV), a ubiquitous human pathogen, is the etiological agent of the fatal neurodegenerative disease progressive multifocal leukoencephalopathy (PML). Like most viruses, JCPyV infection requires the activation of host-cell signaling pathways in order to promote viral replication processes. Previous works have established the necessity of the extracellular signal-regulated kinase (ERK), the...

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PMID: 31561471
DOI: 10.3390/ijms20194779

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