Article
Molecular cancer phenotype in normal prostate tissue.
European urology - 1 Apr 2009
Schlomm Thorsten, Hellwinkel Olaf J C, Buness Andreas, Ruschhaupt Markus, Lübke Andreas M, Chun Felix K, Simon Ronald, Budäus Lars, Erbersdobler Andreas, Graefen Markus, Huland Hartwig, Poustka Annemarie, Sültmann Holger
Abstract excerpt
BACKGROUND: Insufficient sensitivity and specificity of prostate biopsies for cancer detection. OBJECTIVES: Based on evidence from our microarray analyses, we hypothesized that considerable molecular changes precede morphologically detectable malignant transformation of prostate epithelial tissues. The identification of such changes could lead to novel strategies in the clinical management of prostate cancer....
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