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Article

Retroviral integrase domains: DNA binding and the recognition of LTR sequences.

Nucleic acids research - 25 Feb 1991

Khan E, Mack J P, Katz R A, Kulkosky J, Skalka A M

Abstract excerpt

Integration of retroviral DNA into the host chromosome requires a virus-encoded integrase (IN). IN recognizes, cuts and then joins specific viral DNA sequences (LTR ends) to essentially random sites in host DNA. We have used computer-assisted protein alignments and mutagenesis in an attempt to localize these functions within the avian retroviral IN protein. A comparison of the deduced amino acid sequences for 80...

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Identifiers

PMID: 1850126
DOI: 10.1093/nar/19.4.851
PMCID: PMC333721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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