Article
Retroviral integrase domains: DNA binding and the recognition of LTR sequences.
Nucleic acids research - 25 Feb 1991
Khan E, Mack J P, Katz R A, Kulkosky J, Skalka A M
Abstract excerpt
Integration of retroviral DNA into the host chromosome requires a virus-encoded integrase (IN). IN recognizes, cuts and then joins specific viral DNA sequences (LTR ends) to essentially random sites in host DNA. We have used computer-assisted protein alignments and mutagenesis in an attempt to localize these functions within the avian retroviral IN protein. A comparison of the deduced amino acid sequences for 80...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromatography, Affinity
- DNA Nucleotidyltransferases
- DNA Transposable Elements
- DNA, Viral
- Integrases
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Retroviridae