Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death.

The Journal of biological chemistry - 12 Aug 2005

Seki Takahiro, Adachi Naoko, Ono Yoshitaka, Mochizuki Hideki, Hiramoto Keiko, Amano Taku, Matsubayashi Hiroaki, Matsumoto Masayasu, Kawakami Hideshi, Saito Naoaki, Sakai Norio

Abstract excerpt

Spinocerebellar ataxia type 14 (SCA14) is an autosomal dominant neurodegenerative disease characterized by various symptoms including cerebellar ataxia. Recently, several missense mutations in the protein kinase Cgamma (gammaPKC) gene have been found in different SCA14 families. To elucidate how...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Aggregation
Share to Cell Death
Share to Coloring Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Detergents

Share to Golgi Apparatus

Share to Octoxynol

Share to Protein Kinase C

Share to Spinocerebellar Ataxias

Source

Identifiers

PMID: 15964845
DOI: 10.1074/jbc.M501716200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15964845-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death.PMID 15964845Read ↗

Activation of mutant protein kinase Cgamma leads to aberrant sequestration and impairment of its cellular function.Semantic proximity Read ↗

Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis.Semantic proximity Read ↗

Molecular pathophysiology of neurodegenerative disease caused by γPKC mutations.Semantic proximity Read ↗

Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress.Semantic proximity Read ↗

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.Semantic proximity Read ↗

R659S mutation of gammaPKC is susceptible to cell death: implication of this mutation/polymorphism in the pathogenesis of retinitis pigmentosa.Semantic proximity Read ↗

Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.Semantic proximity Read ↗

PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling.Semantic proximity Read ↗

Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14.Semantic proximity Read ↗

Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14.Semantic proximity Read ↗

Protein Kinase Cγ Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing AutoinhibitionSemantic proximity Read ↗

Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.