Article
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients.
Folia biologica - 1 Jan 2008
Ozger H, Kilicoglu O, Yilmaz H, Ergen H A, Yaylim I, Zeybek U, Isbir T
Abstract excerpt
This study was designed to investigate the association of MTHFR C677T polymorphism and the risk of two common musculoskeletal sarcomas, osteosarcoma and chondrosarcoma. MTHFR genotypes were determined in 56 patients (44 osteosarcoma, 12 chondrosarcoma) and 44 controls using the PCR-RFLP technique. In the gender subgroup analysis, wild-type A allele frequency was higher in male osteosarcoma patients than in male...
Topics
- Adolescent
- Adult
- Alleles
- Chondrosarcoma
- Female
- Genotype
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Osteosarcoma
- Polymorphism, Genetic