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Article

Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2009

Wartosch Lena, Fuhrmann Jens C, Schweizer Michaela, Stauber Tobias, Jentsch Thomas J

Abstract excerpt

Mutations in either ClC-7, a late endosomal/lysosomal member of the CLC family of chloride channels and transporters, or in its beta-subunit Ostm1 cause osteopetrosis and lysosomal storage disease in mice and humans. The severe phenotype of mice globally deleted for ClC-7 or Ostm1 and the absence of storage material in cultured cells hampered investigations of the mechanism leading to lysosomal pathology in the...

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Identifiers

PMID: 19661288
DOI: 10.1096/fj.09-130880

Genes

CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7.PMID 19661288Read ↗

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function.Semantic proximity Read ↗

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Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl-/H+ Exchanger ClC-7.Semantic proximity Read ↗

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.Semantic proximity Read ↗

Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1.Semantic proximity Read ↗

Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.Semantic proximity Read ↗

Pathobiologic Mechanisms of Neurodegeneration in Osteopetrosis Derived From Structural and Functional Analysis of 14 ClC-7 Mutants.Semantic proximity Read ↗

A model of lysosomal pH regulation.Semantic proximity Read ↗

ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity.Semantic proximity Read ↗

CLCN7, a gene shared by autosomal recessive and autosomal dominant osteopetrosis.Semantic proximity Read ↗

Characterization of the bone phenotype in ClC-7-deficient mice.Semantic proximity Read ↗

Null mutation of chloride channel 7 (Clcn7) impairs dental root formation but does not affect enamel mineralization.Semantic proximity Read ↗

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