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Article

Mechanical phenotyping of mouse embryonic stem cells: increase in stiffness with differentiation.

Cellular reprogramming - 1 Aug 2011

Pillarisetti Anand, Desai Jaydev P, Ladjal Hamid, Schiffmacher Andrew, Ferreira Antoine, Keefer Carol L

Abstract excerpt

Atomic force microscopy (AFM) has emerged as a promising tool to characterize the mechanical properties of biological materials and cells. In our studies, undifferentiated and early differentiating mouse embryonic stem cells (mESCs) were assessed individually using an AFM system to determine if we could detect changes in their mechanical properties by surface probing. Probes with pyramidal and spherical tips were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21728815
DOI: 10.1089/cell.2011.0028

Genes

AFM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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