Exploring the Impact of LRRK2 WD40 G2294R Mutation on Conformation and Dimerisation Dynamics: Insights From Molecular Dynamics Simulation.

Abstract excerpt

LRRK2 has gained prominence in treating Parkinson's disease as a potential drug target. Mutations in the WD40 domain, like G2294R, are notable for their influence on the stability and dimerisation of the LRRK2. Studies have shown that G2294R could result in the WD40 distortion and destabilised LRRK2 protein. However, the underlying mechanism remains unclear. To elucidate how the G2294R mutation in the WD40 domain...

Topics

• Molecular Dynamics Simulation
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Humans
• Protein Multimerization
• Mutation
• Protein Conformation