Article
Polymorphism of Trp64Arg in beta3-adrenergic receptor gene and serum LDL-cholesterol concentrations in healthy Japanese.
Annals of clinical biochemistry - 1 May 2008
Kotani Kazuhiko, Sakane Naoki, Kurozawa Youichi, Kaetsu Akihiko, Okamoto Mikizo, Osaki Yoneatsu, Kishimoto Takuji
Abstract excerpt
BACKGROUND: Polymorphism of Trp64Arg in the beta(3)-adrenergic receptor (beta(3)-AR) gene may play a critical role in lipid and lipoprotein metabolism by mediating lipolysis and thermogenesis. Since the frequency of Arg alleles of the beta(3)-AR gene is generally low among many populations, studies on the Arg/Arg genotype in relation to lipid and lipoprotein metabolism are required in countries such as Japan...
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