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Article

Rational Design of Highly Active and Selective Ligands for the α5β1 Integrin Receptor

15 May 2008

Abstract excerpt

The inhibition of integrin function is a major challenge in medicinal chemistry. Potent ligands are currently in different stages of clinical trials for the antiangiogenic therapy of cancer and age-related macula degeneration (AMD). The subtype alpha5beta1 has recently been drawn into the focus of research because of its genuine role in angiogenesis. In our previous work we could demonstrate that the lack of...

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PMID: 18481343
DOI: 10.1002/cbic.200800045

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