Article
Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene.
The Journal of biological chemistry - 25 Feb 1991
Fink J S, Verhave M, Walton K, Mandel G, Goodman R H
Abstract excerpt
Transcription of the human vasoactive intestinal peptide (VIP) gene is regulated by both cyclic AMP and phorbol esters. A 17-nucleotide enhancer element within the human VIP gene mediates transcriptional activation by both phorbol esters and forskolin. Mutations of this element decrease responses...
Topics
- Base Sequence
- Blotting, Northern
- Colforsin
- Cyclic AMP
- Electrophoresis, Polyacrylamide Gel
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Metallothionein
- Molecular Sequence Data
- Mutation
- Plasmids
- RNA, Messenger
- Second Messenger Systems
- Tetradecanoylphorbol Acetate
- Transcription, Genetic
- Vasoactive Intestinal Peptide