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Article

A novel role of VIP in colonic motility function: induction of excitation-transcription coupling in smooth muscle cells.

Gastroenterology - 1 Apr 2007

Shi Xuan-Zheng, Choudhury Barun K, Pasricha Pankaj J, Sarna Sushil K

Abstract excerpt

BACKGROUND & AIMS: Vasoactive intestinal polypeptide (VIP) relaxes smooth muscle by generation of cAMP and activation of protein kinase A (PKA). However, PKA activation also phosphorylates the transcription factor CREB. The aim of this study was to investigate whether the phosphorylation of CREB induces gene expression of the pore-forming alpha(1C) subunit of Ca(v)1.2 channels (L-type calcium channels), whose...

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Source

Identifiers

PMID: 17408637
DOI: 10.1053/j.gastro.2007.02.016

Genes

VIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel role of VIP in colonic motility function: induction of excitation-transcription coupling in smooth muscle cells.PMID 17408637Read ↗

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