Article
A novel role of VIP in colonic motility function: induction of excitation-transcription coupling in smooth muscle cells.
Gastroenterology - 1 Apr 2007
Shi Xuan-Zheng, Choudhury Barun K, Pasricha Pankaj J, Sarna Sushil K
Abstract excerpt
BACKGROUND & AIMS: Vasoactive intestinal polypeptide (VIP) relaxes smooth muscle by generation of cAMP and activation of protein kinase A (PKA). However, PKA activation also phosphorylates the transcription factor CREB. The aim of this study was to investigate whether the phosphorylation of CREB...
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