Article
A prevalence-based association test for case-control studies.
Genetic epidemiology - 1 Nov 2008
Ryckman Kelli K, Jiang Lan, Li Chun, Bartlett Jacquelaine, Haines Jonathan L, Williams Scott M
Abstract excerpt
Genetic association is often determined in case-control studies by the differential distribution of alleles or genotypes. Recent work has demonstrated that association can also be assessed by deviations from the expected distributions of alleles or genotypes. Specifically, multiple methods motivated by the principles of Hardy-Weinberg equilibrium (HWE) have been developed. However, these methods do not take into...
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