Article
Two zinc finger transcription factors, CrzA and SltA, are involved in cation homoeostasis and detoxification in Aspergillus nidulans.
The Biochemical journal - 15 Sept 2008
Spielvogel Anja, Findon Helen, Arst Herbert N, Araújo-Bazán Lidia, Hernández-Ortíz Patricia, Stahl Ulf, Meyer Vera, Espeso Eduardo A
Abstract excerpt
To investigate cation adaptation and homoeostasis in Aspergillus nidulans, two transcription-factor-encoding genes have been characterized. The A. nidulans orthologue crzA of the Saccharomyces cerevisiae CRZ1 gene, encoding a transcription factor mediating gene regulation by Ca(2+), has been identified and deleted. The crzA deletion phenotype includes extreme sensitivity to alkaline pH, Ca(2+) toxicity and...
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