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Article

Herpes Simplex Virus 1 Small Noncoding RNAs 1 and 2 Activate the Herpesvirus Entry Mediator Promoter.

Journal of virology - 9 Feb 2022

Tormanen Kati, Wang Shaohui, Matundan Harry H, Yu Jack, Jaggi Ujjaldeep, Ghiasi Homayon

Abstract excerpt

Herpes simplex virus 1 (HSV-1) latency-associated transcript (LAT) plays a significant role in efficient establishment of latency and reactivation. LAT has antiapoptotic activity and downregulates expression of components of the type I interferon pathway. LAT also specifically activates expression of the herpesvirus entry mediator (HVEM), one of seven known receptors used by HSV-1 for cell entry that is crucial...

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Identifiers

PMID: 34851143
DOI: 10.1128/JVI.01985-21
PMCID: PMC8826802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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