Article
Poliovirus-induced apoptosis is reduced in cells expressing a mutant CD155 selected during persistent poliovirus infection in neuroblastoma cells.
Journal of virology - 1 Jan 2003
Gosselin Anne-Sophie, Simonin Yannick, Guivel-Benhassine Florence, Rincheval Vincent, Vayssière Jean-Luc, Mignotte Bernard, Colbère-Garapin Florence, Couderc Thérèse, Blondel Bruno
Abstract excerpt
Poliovirus (PV) can establish persistent infections in human neuroblastoma IMR-32 cells. We previously showed that during persistent infection, specific mutations were selected in the first extracellular domain of the PV receptor (CD155) of these cells (N. Pavio, T. Couderc, S. Girard, J. Y. Sgro, B. Blondel, and F. Colbère-Garapin, Virology 274:331-342, 2000). These mutations included the Ala 67 --> Thr...
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