Article
Association of genetic variation in ENPP1 with obesity-related phenotypes.
Obesity (Silver Spring, Md.) - 1 Jul 2008
Jenkinson Christopher P, Coletta Dawn K, Flechtner-Mors Marion, Hu Shirley L, Fourcaudot Marcel J, Rodriguez Lenore M, Schneider Jennifer, Arya Rector, Stern Michael P, Blangero John, Duggirala Ravindranath, DeFronzo Ralph A
Abstract excerpt
Ectonucleotide pyrophosphatase phosphodiesterase (ENPP1) is a positional candidate gene at chromosome 6q23 where we previously detected strong linkage with fasting-specific plasma insulin and obesity in Mexican Americans from the San Antonio Family Diabetes Study (SAFDS). We genotyped 106 single-nucleotide polymorphisms (SNPs) within ENPP1 in all 439 subjects from the linkage study, and measured association with...
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