Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.

doi:10.1038/ng1604

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Article

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.

Nature genetics - 1 Aug 2005

Meyre David, Bouatia-Naji Nabila, Tounian Agnès, Samson Chantal, Lecoeur Cécile, Vatin Vincent, Ghoussaini Maya, Wachter Christophe, Hercberg Serge, Charpentier Guillaume, Patsch Wolfgang, Pattou François, Charles Marie-Aline, Tounian Patrick, Clément Karine, Jouret Béatrice, Weill Jacques, Maddux Betty A, Goldfine Ira D, Walley Andrew, Boutin Philippe, Dina Christian, Froguel Philippe

Abstract excerpt

We identified a locus on chromosome 6q16.3-q24.2 (ref. 1) associated with childhood obesity that includes 2.4 Mb common to eight genome scans for type 2 diabetes (T2D) or obesity. Analysis of the gene ENPP1 (also called PC-1), a candidate for insulin resistance, in 6,147 subjects showed association between a three-allele risk haplotype (K121Q, IVS20delT-11 and A-->G+1044TGA; QdelTG) and childhood obesity (odds...

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PMID: 16025115
DOI: 10.1038/ng1604
PMCID: PMC2000804

Genes

ENPP1

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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.PMID 16025115Read ↗

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