Article
Genetic determination of cytomegalovirus-induced and age-related cardiopathy in inbred mice. Characterization of infiltrating cells.
The American journal of pathology - 1 Jan 1991
Price P, Eddy K S, Papadimitriou J M, Faulkner D L, Shellam G R
Abstract excerpt
Carditis developed 7 days after the administration of murine cytomegalovirus to neonatal, young adult or aged mice of varying sensitivity to lethal infection with this virus. The inflammation persisted for up to 80 days, but infected myocardial cells were rare and were not seen after day 10. The inflammatory cells comprised macrophages (up to 30%) and T cells (up to 80%), with a high ratio of Lyt2+ to L3T4+ cells...
Topics
- Aging
- Animals
- Cell Movement
- Cytomegalovirus Infections
- Fibrosis
- Mice
- Mice, Inbred Strains
- Myocarditis
- Myocardium
- Necrosis
- Phenotype