Article
Sendai viral pneumonia in aged BALB/c mice.
Experimental gerontology - 1 Jan 2000
Jacoby R O, Bhatt P N, Barthold S W, Brownstein D G
Abstract excerpt
Sendai virus (SV) infection in aged BALB/c mice was evaluated as a natural model for age-associated susceptibility to viral pneumonia. Young (2 month-old) and aged (22-24 month-old) BALB/c mice were inoculated intranasally with 100 median pneumonia doses (PD50) of SV and examined at 6, 10, and 20 days by virus titration, immunohistochemistry, histopathology, and serology. The aged mice had significantly higher...
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