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Article

Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes.

Immunology - 1 Nov 2008

Orlowski Robert J, O'Rourke Kenneth S, Olorenshaw Irene, Hawkins Gregory A, Maas Stefan, Laxminarayana Dama

Abstract excerpt

The aetiopathogenesis of the abnormal immune response in systemic lupus erythematosus (SLE) remains incompletely understood. We and other investigators demonstrated altered expression of adenosine deaminase that act on RNA (ADAR) genes in SLE patients. Based on this information, we hypothesize that the altered expression and function of ADAR enzymes is a mechanism for the immunopathogenesis of SLE. ADARs edit...

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Share to 3',5'-Cyclic-AMP Phosphodiesterases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-alpha

Share to Lupus Erythematosus, Systemic

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Source

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Identifiers

PMID: 18462347
DOI: 10.1111/j.1365-2567.2008.02850.x
PMCID: PMC2669144

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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