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Article

Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis.

PLoS medicine - 6 May 2008

Meltzer Mirjam E, Lisman Ton, Doggen Carine J M, de Groot Philip G, Rosendaal Frits R

Abstract excerpt

BACKGROUND: Previously, we demonstrated that hypofibrinolysis, a decreased capacity to dissolve a blood clot as measured with an overall clot lysis assay, increases the risk of venous thrombosis. Here, we investigated the combined effect of hypofibrinolysis with established risk factors associated with hypercoagulability. METHODS AND FINDINGS: Fibrinolytic potential was determined with a plasma-based clot lysis...

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Source

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Identifiers

PMID: 18462012
DOI: 10.1371/journal.pmed.0050097
PMCID: PMC2365975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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