Article
The essential in vivo function of the herpes simplex virus UL42 protein correlates with its ability to stimulate the viral DNA polymerase in vitro.
Virology - 1 May 1994
Reddig P J, Grinstead L A, Monahan S J, Johnson P A, Parris D S
Abstract excerpt
The product of the UL42 gene of herpes simplex virus type 1 (HSV-1) is an essential protein required for viral DNA synthesis in both transient origin of replication-dependent DNA replication assays and in virus-infected cells. In vitro, UL42 has been shown to form a heterodimeric complex with the...
Topics
- Animals
- Blotting, Western
- Cricetinae
- DNA Mutational Analysis
- DNA-Directed DNA Polymerase
- Enzyme Induction
- Exodeoxyribonucleases
- Genetic Complementation Test
- Herpesvirus 1, Human
- Immediate-Early Proteins
- Kidney
- Mutation
- Species Specificity
- Vero Cells
- Viral Proteins
- Virus Replication