Article
[MALDI-ToF mass-spectrometry in analysis of genetically determined resistance of Streptococcus pneumoniae to fluoroquinolones].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Jan 2007
Malakhova M V, Vereshchagin V A, Il'ina E N, Govorun V M, Filimonova O Iu, Grudinina S A, Sidorenko S V
Abstract excerpt
New fluoroquinolones with higher antipneumococcal activity are considered promising in the treatment of respiratory tract infections. Still, their wide use in clinical practice is connected with possible selection and rapid distribution of the resistance, requiring constant monitoring. Development of resistance to fluoroquinolones results from step-wise accumulation of mutations in the genes of DNA-gyrase and...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Multiple, Bacterial
- Fluoroquinolones
- Microbial Sensitivity Tests
- Mutation
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization