Article
From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30.
Proceedings of the National Academy of Sciences of the United States of America - 28 May 2002
Walsh Tom, Walsh Vanessa, Vreugde Sarah, Hertzano Ronna, Shahin Hashem, Haika Smadar, Lee Ming K, Kanaan Moien, King Mary-Claire, Avraham Karen B
Abstract excerpt
Normal vision in Drosophila requires NINAC, a class III myosin. Class III myosins are hybrid motor-signaling molecules, with an N-terminal kinase domain, highly conserved head and neck domains, and a class III-specific tail domain. In Drosophila rhabdomeres, NINAC interacts with actin filaments and with a PDZ scaffolding protein to organize the phototransduction machinery into a signaling complex. Recessive null...
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