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Article

Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury.

Shock (Augusta, Ga.) - 1 Dec 2008

Kobbe Philipp, Kaczorowski David J, Vodovotz Yoram, Tzioupis Christopher H, Mollen Kevin P, Billiar Timothy R, Pape Hans-Christoph

Abstract excerpt

Remote and systemic inflammatory responses after long bone fractures have been well described, but the mechanisms underlying these changes remain unexplained. We hypothesized that bone components locally exposed to injured soft tissue are capable of inducing a systemic inflammatory response associated with acute lung injury, and that this inflammatory cascade requires Toll-like receptor 4 (TLR-4) signaling....

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PMID: 18461022
DOI: 10.1097/SHK.0b013e31816f257e

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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