Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BMP Ligand Trap ALK3-Fc Attenuates Osteogenesis and Heterotopic Ossification in Blast-Related Lower Extremity Trauma

1 Dec 2020

Abstract excerpt

Traumatic heterotopic ossification (tHO) commonly develops in wounded service members who sustain high-energy and blast-related traumatic amputations. Currently, no safe and effective preventive measures have been identified for this patient population. Bone morphogenetic protein (BMP) signaling blockade has previously been shown to reduce ectopic bone formation in genetic models of HO. In this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heterotopic Ossification and Related Conditions
Share to Parathyroid Disorders and Treatments
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33256557
DOI: 10.1089/scd.2020.0162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BMP Ligand Trap ALK3-Fc Attenuates Osteogenesis and Heterotopic Ossification in Blast-Related Lower Extremity TraumaPMID 33256557Read ↗

Burn-induced heterotopic ossification from incidence to therapy: key signaling pathways underlying ectopic bone formationSemantic proximity Read ↗

Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.Semantic proximity Read ↗

The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and DiseaseSemantic proximity Read ↗

Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities.Semantic proximity Read ↗

Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossificationSemantic proximity Read ↗

Murine Tissue-Resident PDGFRα+ Fibro-Adipogenic Progenitors Spontaneously Acquire Osteogenic Phenotype in an Altered Inflammatory Environment.Semantic proximity Read ↗

A review of the biomarkers and in vivo models for the diagnosis and treatment of heterotopic ossification following blast and trauma-induced injuriesSemantic proximity Read ↗

Heterotopic Ossification: Molecular Drivers, Subtype-Specific Mechanisms, and Translational Therapeutic Advances.Semantic proximity Read ↗

Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1R206H Mouse Model of Fibrodysplasia Ossificans Progressiva.Semantic proximity Read ↗

BMPs and their clinical potentialsSemantic proximity Read ↗

Human Umbilical Cord–Derived Mesenchymal Stromal Cell Therapy Modulates Inflammation in Mine-Explosive Wounds in Humans: A Transcriptomic StudySemantic proximity Read ↗

Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.