In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential.

doi:10.1128/JVI.65.1.292-298.1991

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Article

In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential.

Journal of virology - 1 Jan 1991

Barbosa M S, Vass W C, Lowy D R, Schiller J T

Abstract excerpt

Human papillomavirus type 16 (HPV-16) and HPV-18 are often detected in cervical carcinomas, while HPV-6, although frequently present in benign genital lesions, is only rarely present in cancers of the cervix. Therefore, infections with HPV-16 and HPV-18 are considered high risk and infection with HPV-6 is considered low risk. We found, by using a heterologous promoter system, that expression of the E7...

Topics

Animals
Cell Division
Cell Line
Cell Transformation, Neoplastic
Cells, Cultured
Cloning, Molecular
Cysteine
Genes, Viral
Genetic Complementation Test
Genetic Variation
Harvey murine sarcoma virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Keratinocytes

Male

Mice

Moloney murine sarcoma virus

Open Reading Frames

Papillomaviridae

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Identifiers

PMID: 1845889
DOI: 10.1128/JVI.65.1.292-298.1991
PMCID: PMC240516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1845889-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential.PMID 1845889Read ↗

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in cultureSemantic proximity Read ↗

The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18Semantic proximity Read ↗

Papillomavirus E6 and E7 proteins and their cellular targetsSemantic proximity Read ↗

Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1Semantic proximity Read ↗

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cellsSemantic proximity Read ↗

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequencesSemantic proximity Read ↗

Roles of the E6 and E7 proteins in the life cycle of low-risk human papillomavirus type 11.Semantic proximity Read ↗

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genesSemantic proximity Read ↗

The E5 Gene of HPV-16 Enhances Keratinocyte Immortalization by Full-Length DNASemantic proximity Read ↗

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cellsSemantic proximity Read ↗

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.Semantic proximity Read ↗

Dispensability of p53 degradation for tumorigenicity and decreased serum requirement of human papillomavirus type 16 E6.Semantic proximity Read ↗

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