Article
Impact of the RNA chaperone Hfq on the fitness and virulence potential of uropathogenic Escherichia coli.
Infection and immunity - 1 Jul 2008
Kulesus Richard R, Diaz-Perez Karen, Slechta E Susan, Eto Danelle S, Mulvey Matthew A
Abstract excerpt
Hfq is a bacterial RNA chaperone involved in the posttranscriptional regulation of many stress-inducible genes via small noncoding RNAs. Here, we show that Hfq is critical for the uropathogenic Escherichia coli (UPEC) isolate UTI89 to effectively colonize the bladder and kidneys in a murine urinary tract infection model system. The disruption of hfq did not affect bacterial adherence to or invasion of host cells...
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