Article
Impact of the RNA chaperone Hfq on the fitness and virulence potential of uropathogenic Escherichia coli.
Infection and immunity - 1 Jul 2008
Kulesus Richard R, Diaz-Perez Karen, Slechta E Susan, Eto Danelle S, Mulvey Matthew A
Abstract excerpt
Hfq is a bacterial RNA chaperone involved in the posttranscriptional regulation of many stress-inducible genes via small noncoding RNAs. Here, we show that Hfq is critical for the uropathogenic Escherichia coli (UPEC) isolate UTI89 to effectively colonize the bladder and kidneys in a murine urinary tract infection model system. The disruption of hfq did not affect bacterial adherence to or invasion of host cells...
Topics
- Animals
- Anti-Bacterial Agents
- Biofilms
- Drug Resistance, Bacterial
- Escherichia coli
- Escherichia coli Infections
- Female
- Gene Expression Regulation, Bacterial
- Host Factor 1 Protein
- Humans
- Mice
- Mice, Inbred CBA
- Molecular Chaperones