Article
Insights into anti-termination regulation of the hut operon in Bacillus subtilis: importance of the dual RNA-binding surfaces of HutP.
Nucleic acids research - 1 Jun 2008
Gopinath Subash C B, Balasundaresan Dhakshnamoorthy, Kumarevel Thirumananseri, Misono Tomoko S, Mizuno Hiroshi, Kumar Penmetcha K R
Abstract excerpt
The anti-termination protein, HutP, regulates the gene expression of the hut (histidine utilization) operon of Bacillus subtilis, by destabilizing the hut terminator RNA located upstream of the coding region encoding l-histidine degradation enzymes. On the basis of biochemical, in vivo and X-ray structural analyses, we now report that HutP uses its dual RNA-binding surfaces to access two XAG-rich regions (sites I...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.