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Article

Helicobacter pylori Depletes Cholesterol in Gastric Glands to Prevent Interferon Gamma Signaling and Escape the Inflammatory Response.

Gastroenterology - 1 Apr 2018

Morey Pau, Pfannkuch Lennart, Pang Ervinna, Boccellato Francesco, Sigal Michael, Imai-Matsushima Aki, Dyer Victoria, Koch Manuel, Mollenkopf Hans-Joachim, Schlaermann Philipp, Meyer Thomas F

Abstract excerpt

BACKGROUND & AIMS: Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of cholesterol-α-glucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. We investigated how cgt affects gastric epithelial cells and the host immune response. METHODS: MKN45 gastric epithelial cells, AGS cells, and human...

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Source

Identifiers

PMID: 29273450
DOI: 10.1053/j.gastro.2017.12.008

Genes

IFNG
STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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