Article
Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide.
European heart journal - 1 Jun 2008
van Driel Lydi M J W, Smedts Huberdina P M, Helbing Willem A, Isaacs Aaron, Lindemans Jan, Uitterlinden André G, van Duijn Cornelia M, de Vries Jeanne H M, Steegers Eric A P, Steegers-Theunissen Régine P M
Abstract excerpt
AIMS: Congenital heart defects (CHDs) have a multifactorial origin, in which subtle genetic factors and peri-conception exposures interact. We hypothesize that derangements in the homocysteine and detoxification pathways, due to a polymorphism in the nicotinamide N-methyltransferase (NNMT) gene, low maternal dietary nicotinamide intake, and medicine use in the peri-conception period, affect CHD risk. METHODS AND...
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