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Article

Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy.

Human molecular genetics - 1 Aug 2008

Wehling-Henricks Michelle, Sokolow Sophie, Lee Jamie J, Myung Kyu H, Villalta S Armando, Tidball James G

Abstract excerpt

The immune response to dystrophin-deficient muscle promotes the pathology of Duchenne muscular dystrophy (DMD) and the mdx mouse model of DMD. In this investigation, we find that the release of major basic protein (MBP) by eosinophils is a prominent feature of DMD and mdx dystrophy and that eosinophils lyse muscle cells in vitro by the release of MBP-1. We also show that eosinophil depletions of mdx mice by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred mdx

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Share to Muscular Dystrophy, Duchenne

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Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 18430716
DOI: 10.1093/hmg/ddn129
PMCID: PMC2574717

Genes

MBP
DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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